The third edition of this encyclopedia continues the focus on the discovery, development, design, manufacture, testing, regulation, and commercialization of drugs and dosage forms. Areas of emphasis include pharmaceutics, pharmacokinetics, analytical chemistry, quality assurance, drug safety, and manufacturing processes. Both more traditional and newer technologies and processes are included, with an increased emphasis on biotechnology and large molecule development. Current trends relating to solid state aspects of drug entities are also included, reflecting again the advances made in this area.
While of primary interest to pharmaceutical scientists and management in the pharmaceutical and related industries, including regulatory agencies, the encyclopedia will be of value to those in academia undertaking pharmaceutical research and those responsible for the education and training in pharmaceutical science and technology of graduate and undergraduate students.
The print version of the third edition consists of six volumes totaling about 4400 pages, an approximately 45% increase in content compared to the second edition. The number of articles has increased to almost 300 titles arranged alphabetically by subject and the number of contributors has risen by over 50% to in excess of 500 individuals. The new edition now contains a Topical Table of Contents, whose purpose is to group article titles into categories and subcategories, thereby making the reader aware of other related and relevant articles.
As was the case with the second edition, the online version includes everything in the print version and also offers the convenience of a keyword search engine as well as the inclusion of color illustrations. New and revise articles will be digitally posted quarterly and available to all subscribers of the electronic version.
Contents
Volume1
- 21 CFR Part 11 Revisited
- Absorption Enhancers
- Absorption of Drugs
- Adsorption at Solid Surfaces: Pharmaceutical Applications
- Adverse Drug Reactions
- Advertising and Promotion of Prescription and Over-the-Counter Drug Products
- Alternative Medicines
- Amorphous Pharmaceutical Systems
- Analytical Procedures: Validation
- Animals in Drug Development
- Aseptic Processing: Validation
- Autoxidation and Antioxidants
- Bioabsorbable Polymers
- Bioavailability of Drugs and Bioequivalence
- Biodegradable Polymers as Drug Carriers
- Biologic Fluids: Analysis
- Biopharmaceutics
- Biosynthesis of Drugs
- Biotechnology and Biological Preparations
- Biotechnology-Derived Drug Products: Formulation Development
- Biotechnology-Derived Drug Products: Stability Testing, Filling, and Packaging
- Biotransformation of Drugs
- Bio-Validation of Steam Sterilization
- Blood Substitutes: Fluorocarbon Approach
- Blood Substitutes: Hemoglobin-Based Oxygen Carriers
- Blow-Fill-Seal: Advanced Aseptic Processing
- Buffers, Buffering Agents, and Ionic Equilibria
- Calorimetry in Pharmaceutical Research and Development
- Capsules, Hard
- Capsules, Soft
- Carcinogenicity Testing: Past, Present, and Future
- Chiroptical Analytical Methods
- Chromatographic Methods of Analysis: Gas Chromatography
- Chromatographic Methods of Analysis: High Performance Liquid Chromatography
- Chromatographic Methods of Analysis: Thin Layer Chromatography
- Clinical Data Management Systems
- Clinical Evaluation of Drugs
- Clinical Pharmacokinetics and Pharmacodynamics
- Clinical Supplies Manufacture: GMP Considerations
- Coacervation and Phase Separation
- Cocrystals: Design, Properties and Formation Mechanisms
- Colloids and Colloid Drug Delivery System
- Coloring Agents for Use in Pharmaceuticals
- Index
Volume 2
- Complexation: Cyclodextrins
- Complexation: Non-Cyclodextrins
- Computer Systems Validation
- Computer-Assisted Drug Design
- Computers in Pharmaceutical Technology
- Continuous Processing of Pharmaceuticals
- Contract Manufacturing
- Cooling Processes and Congealing
- Coprecipitates and Melts
- Corrosion of Pharmaceutical Equipment
- Cosmetics and Their Relation to Drugs
- Cosolvents and Cosolvency
- Crystal Habit Changes and Dosage Form Performance
- Crystallization: General Principles and Significance on Product Development
- Crystallization: Particle Size Control
- Dendrimers
- Dental Products
- Dissolution and Dissolution Testing
- DNA Probes for the Identification of Microbes
- Dosage Form Design: A Physicochemical Approach
- Dosage Forms and Basic Preparations: History
- Dosage Forms: Lipid Excipients
- Dosage Forms: Non-Parenterals
- Dosage Forms: Parenterals
- Dosage Regimens and Dose-Response
- Dressings in Wound Management
- Drug Abuse
- Drug Delivery Systems: Neutron Scattering Studies
- Drug Delivery: Buccal Route
- Drug Delivery: Controlled Release
- Drug Delivery: Fast-Dissolve Systems
- Drug Delivery: Liquid Crystals in
- Drug Delivery: Monoclonal Antibodies
- Drug Delivery: Monoclonal Antibodies in Imaging and Therapy
- Drug Delivery: Mucoadhesive Hydrogels
- Drug Delivery: Nanoparticles
- Drug Delivery: Nasal Route
- Drug Delivery: Needle-Free Systems
- Drug Delivery: Ophthalmic Route
- Drug Delivery: Oral Colon-Specific
- Drug Delivery: Oral Route
- Drug Delivery: Parenteral Route
- Drug Delivery: Pulmonary Delivery
- Drug Delivery: Pulsatile Systems
- Drug Delivery: Rectal Route
- Drug Delivery: Topical and Transdermal Routes
- Drug Delivery: Tumor-Targeted Systems
- Drug Delivery: Vaginal Route
- Drug Design: Basic Principles and Applications
- Drug Development Management
- Drug Information Systems
- Drug Interactions
- Drug Master Files
- Drug Safety Evaluation
- Dry Powder Aerosols: Emerging Technologies
- Index
Volume 3
- Drying and Dryers
- Economic Characteristics of the R&D Intensive Pharmaceutical Industry
- Effervescent Pharmaceuticals
- Elastomeric Components for the Pharmaceutical Industry
- Electrical Power Systems for Pharmaceutical Equipment
- Electroanalytical Methods of Analysis: Polarography and Voltammetry
- Electroanalytical Methods of Analysis: Potentiometry
- Electrochemical Detection for Pharmaceutical Analysis
- Electrostatic Charge in Pharmaceutical Systems
- Emulsions and Microemulsions
- Enzyme Immunoassay and Related Bioanalytical Methods
- Equipment Cleaning
- European Agency for the Evaluation of Medicinal Products (EMEA)
- Evaporation and Evaporators
- Excipients for Pharmaceutical Dosage Forms
- Excipients: Parenteral Dosage Forms and Their Role
- Excipients: Powders and Solid Dosage Forms
- Excipients: Safety Testing
- Expert Systems in Pharmaceutical Product Development
- Expiration Dating
- Extractables and Leachables in Drugs and Packaging
- Extrusion and Extruders
- Film Coating of Oral Solid Dosage Forms
- Filters and Filtration
- Flame Photometry
- Flavors and Flavor Modifiers
- Fluid Bed Processes for Forming Functional Particles
- Food and Drug Administration: Role in Drug Regulation
- Fractal Geometry in Pharmaceutical and Biological Applications
- Freeze Drying
- Freeze Drying, Scale-Up Considerations
- Gastro-Retentive Systems
- Gelatin-Containing Formulations: Changes in Dissolution Characteristics
- Gels and Jellies
- Generic Drugs and Generic Equivalency
- Genetic Aspects of Drug Development
- Geriatric Dosing and Dosage Forms
- Good Clinical Practices (GCPs): An Overview
- Good Laboratory Practices (GLPs): An Overview
- Good Manufacturing Practices (GMPs): An Overview
- Handling Hazardous Chemicals and Pharmaceuticals
- Harmonization of Pharmacopeial Standards
- Headspace Oxygen Analysis in Pharmaceutical Products
- Health Care Systems: Outside the United States
- Health Care Systems: Within the United States
- Homogenization and Homogenizers
- Hot-Melt Extrusion Technology
- Hydrogels
- Hydrolysis of Drugs
- Immunoassay
- In Vitro–In Vivo Correlation
- Inhalation: Dry Powder
- Inhalation: Liquids
- Index
Volume 4
- Iontophoresis
- Isolators for Pharmaceutical Application
- Isomerism Laboratory Information Management System (LIMS)
- Laminar Airflow Equipment: Applications and Operation
- Lead Optimization in Pharmaceutical Development: Molecular and Cellular Approaches
- Lens Care Products
- Liquid Oral Preparations
- Lozenges
- Materials of Construction for Pharmaceutical Equipment
- Medication Errors
- Melt Processes for Oral Solid Dosage Forms
- Metabolite Identification in Drug Discovery
- Metered Dose Inhalers
- Microbial Control of Pharmaceuticals
- Microbiologic Monitoring of Controlled Processes
- Microencapsulation Technology
- Microsphere Technology and Applications
- Milling of Active Pharmaceutical Ingredients
- Mixing and Segregation in Tumbling Blenders
- Moisture in Pharmaceutical Products
- Nanoparticle Engineering
- Neural Computing and Formulation Optimization
- Non-Prescription Drugs
- Nutraceutical Supplements
- Optimization Methods
- Orphan Drugs
- Otic Preparations
- Outsourcing
- Packaging Materials: Glass
- Packaging Systems: Compendial Requirements
- Paperless Documentation Systems
- Particle Engineering
- Particle-Size Characterization
- Partition Coefficients
- Patents: International Perspective
- Patents: United States Perspective
- Pediatric Dosing and Dosage Forms
- Pelletization Techniques
- Peptides and Proteins: Buccal Absorption
- Peptides and Proteins: Nasal Absorption
- Peptides and Proteins: Non-Invasive Delivery
- Peptides and Proteins: Oral Absorption
- Peptides and Proteins: Pulmonary Absorption
- Peptides and Proteins: Transdermal Absorption
- Pharmaceutical Data: Mathematical Modeling
- Pharmaceutical Excipient Testing: Regulatory and Preclinical Perspective
- Pharmaceutical Quality Assurance Microbiology Laboratories
- Pharmacogenomics and Genomic Technologies
- Pharmacokinetic/Pharmacodynamic Modeling and Simulations in Drug Development
- Pharmacokinetics: Effects of Food and Fasting
- Index
Volume 5
- Pharmacopeial Standards: European Pharmacopeia = Agne`s Artiges
- Pharmacopeial Standards: Japanese Pharmacopeia = Mitsuru Uchiyama
- Pharmacopeial Standards: United States Pharmacopeia and National Formulary
- Photodecomposition of Drugs
- Physiological Factors Affecting Oral Drug Delivery
- Pilot Plant Design
- Pilot Plant Operation
- Plants as Drugs
- Polymeric Delivery Systems for Poorly Soluble Drugs
- Polymers in Transdermal Delivery Systems
- Polymorphism: Pharmaceutical Aspects
- Population Pharmacokinetics
- Powder Sampling
- Powders as Dosage Forms
- Preservation of Pharmaceutical Products
- Process Chemistry in the Pharmaceutical Industry
- Prodrug Design
- Project Management
- Protein Binding of Drugs
- Proteomics: Pharmaceutical Applications
- Pyrogens and Endotoxin Detection
- Quality Assurance of Pharmaceuticals
- Quality Systems Management
- Radiochemical Methods of Analysis
- Radiolabeling of Pharmaceutical Aerosols and Gamma Scintigraphic Imaging for Lung Deposition
- Receptors for Drugs: Discovery in the Post-Genomic Era
- Rheology of Pharmaceutical Systems
- RNAi in Drug Development
- Roller Compaction Technology for the Pharmaceutical Industry
- Salt Forms: Pharmaceutical Aspects
- Scale-Up and Post Approval Changes (SUPAC)
- Scale-Up of Solid Dosage Forms
- Secondary Electron Microscopy in Pharmaceutical Technology
- Semisolid Preparations
- Solids: Flow Properties
- Solid-State NMR in the Characterization of Pharmaceutical Formulations
- Solubilization of Drugs in Aqueous Media
- Solubilizing Excipients in Pharmaceutical Formulations
- Spectroscopic Methods of Analysis: Atomic Absorption and Emission Spectrophotometry
- Spectroscopic Methods of Analysis: Diffuse Reflectance Spectroscopy
- Spectroscopic Methods of Analysis: Fluorescence Spectroscopy
- Spectroscopic Methods of Analysis: Infrared Spectroscopy
- Spectroscopic Methods of Analysis: Mass Spectrometry
- Spectroscopic Methods of Analysis: Near-Infrared Spectrometry
- Spectroscopic Methods of Analysis: Nuclear Magnetic Resonance Spectroscopy
- Spectroscopic Methods of Analysis: Ultraviolet and Visible Spectrophotometry
- Starches and Starch Derivatives
- Index
Volume 6
- Statistical Methods
- Statistical Process Control and Process Capability
- Sterilization: Dry Heat
- Sterilization: Ethylene Oxide
- Sterilization: Moist Heat
- Sterilization: Radiation
- Super Disintegrants: Characterization and Function
- Supercritical Fluid Technology in Pharmaceutical Research
- Surfactants in Pharmaceutical Products and Systems
- Suspensions
- Tablet Compression: Machine Theory, Design, and Process Troubleshooting
- Tablet Evaluation Using Near-Infrared Spectroscopy
- Tablet Formulation
- Tablet Manufacture
- Tablet Manufacture by Direct Compression
- Tablet Press Instrumentation
- Tablet Testing
- Technology Transfer Considerations for Pharmaceuticals
- Thermal Analysis of Drugs and Drug Products
- Titrimetry
- Tonicity
- Tooling for Tableting
- Trace Level Impurity Analysis
- Transdermal Delivery: Anatomical Site Influence
- Transdermal Delivery: Sonophoresis
- Transdermal Delivery: Technologies
- Ultrasonic Nebulizers
- Unit Processes in Pharmacy: Fundamentals
- Unit Processes in Pharmacy: Operations
- Vaccines and Other Immunological Products
- Validation of Pharmaceutical Processes
- Veterinary Dosage Forms
- Veterinary Pharmaceuticals: Factors Influencing Their Development and Use
- Viral Inactivation Issues in Aseptically Processed Parenterals
- Virtual Screening
- Water for Pharmaceuticals
- Water Sorption of Drugs and Dosage Forms
- Waxes
- Wet Granulation: End-Point Determination and Scale-Up
- World Health Organization (WHO): Global Harmonization of Requirements for Medicinal Products
- X-Ray Powder Diffractometry
- Zeta Potential
- Index
About the Editors
- James Swarbrick, PharmaceuTech, Inc., Pinehurst, North Carolinia, USA.
Product Details
- Hardcover: 5536 pages
- Publisher: Informa Healthcare; 3 edition (October 25, 2007)
- Language: English
- ISBN-10: 084939399X
- ISBN-13: 978-0849393990
- Product Dimensions: 18.3 x 12.6 x 6.1 inches
List Price: $3,000.00